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Lorazepam: Difference between revisions

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==Other agents ==
==Other agents ==
lorazepam>[[phenitoin]]
lorazepam>[[phenytoin]]


===midazolam===
===midazolam===


[[Midazolam]] (or lorazepam i.v.) controls effectively 63-73% early SE<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus]</ref>
[[Midazolam]] (or lorazepam i.v.) controls effectively 63-73% early SE<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus]</ref>
==clonazepam==
==clonazepam==
[[clonazepam]] is more lipophylic that lorazepam, but less lipophilic than [[diazepam]] (Congdon et Forsythe (1980) Epilepsia 21:97)
[[clonazepam]] is more lipophylic that lorazepam, but less lipophilic than [[diazepam]] (Congdon et Forsythe (1980) Epilepsia 21:97)

Revision as of 18:03, 1 April 2016

sufficient lengh of time (viewed as 30 min.period)


Status epilepticus, ILAE view as a seizure that persists for a sufficient lengh of time, maybe 5-10 (focal) minutes. [1]

diazepam

intravenous

Other agents

lorazepam>phenytoin

midazolam

Midazolam (or lorazepam i.v.) controls effectively 63-73% early SE[2]

clonazepam

clonazepam is more lipophylic that lorazepam, but less lipophilic than diazepam (Congdon et Forsythe (1980) Epilepsia 21:97)

Levetirazetam

comparison

Propofol

recruitment problem
see also Trinka et al 2015 Pharmacotherapy for Status Epilepticus Drugs 1491-1521.


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