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Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.
- Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.
- Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.
- Pharmacotherapy for Status Epilepticus
- RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): A double-blind randomized clinical trial of the efficacy of IM midazolam versus IV lorazepam in the pre-hospital treatment of status epilepticus by paramedics