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(S)-2-(2-Oxopyrrolidin-1-yl)butanamide is an anticonvulsant medication used to treat epilepsy. It is the S-enantiomer of etiracetam, structurally similar to the prototypical nootropic drug piracetam.

Levetiracetam inhibits high-voltage-activated calcium channels and reduces calcium release from intraneural stores[1]

Extended release

Medication guide FDA


In myoclonic astatic epilepsy should be used with caution in children[2]

Li XC et al. 2017 Clinical characteristics and electroencephalogram analysis of levetiracetam in the treatment of children with febrile seizure recurrence

Trinka E., et al 2015 Pharmacotherapy for Status Epilepticus Drugs 75:1499

Safraski J.-P.2015

Vrielynck P. Current and emerging treatments for absence seizures in young patients

Jackson J.-L. et al.2015

Caviness J. N. Treatment of myoclonus

deWolfe & Szafarski Levetiracetam use in the critical care setting

Lin CH Levetiracetam in the Treatment of Epileptic Seizures After Liver Transplantation



West syndrome

Mangano S et al. West syndrome followed by juvenile myoclonic epilepsy: a coincidental occurrence?


  1. newer antiepileptic drugs
  2. Paradoxical exacerbation of myoclonic-astatic seizures by levetiracetam in myoclonic astatic epilepsy. BMC paediatrics 15 6

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