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Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. The kindling model was first proposed in the late 1960s by Goddard and colleagues. Although kindling is a widely used model, its applicability to human epilepsy is controversial.
The word kindling is a metaphor: the increase in response to small stimuli is similar to the way small burning twigs can produce a large fire. It is used by scientists to study the effects of repeated seizures on the brain. A seizure may increase the likelihood that more seizures will occur; an old saying in epilepsy research is "seizures beget seizures".
- Interaction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy
- Anti-kindling Effect of Bezafibrate, a Peroxisome Proliferator-activated Receptors Alpha Agonist, in Pentylenetetrazole Induced Kindling Seizure Model
- Claustral Lesions Delay Amygdaloid Kindling in the Rat
- Bertram E (2007). "The relevance of kindling for human epilepsy". Epilepsia 48 (Supplement 2): 65–74. doi:10.1111/j.1528-1167.2007.01068.x. PMID 17571354.
- Sato M (2008). "Kindling: An experimental model of epilepsy" (PDF). Psychiatry and Clinical Neurosciences 36 (4): 440–441. doi:10.1111/j.1440-1819.1982.tb03123.x. http://www3.interscience.wiley.com/cgi-bin/fulltext/120156204/PDFSTART.
- wikipedia:Kindling model