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(S)-2-(2-Oxopyrrolidin-1-yl)butanamide is an anticonvulsant medication used to treat [[epilepsy]]. It is the S-enantiomer of [[etiracetam]], structurally similar to the prototypical nootropic drug [[piracetam]].
(S)-2-(2-Oxopyrrolidin-1-yl)butanamide is an anticonvulsant medication used to treat [[epilepsy]]. It is the S-enantiomer of [[etiracetam]], structurally similar to the prototypical nootropic drug [[piracetam]].
Levetiracetam inhibits high-voltage-activated calcium channels and reduces calcium release from intraneural stores<ref>[http://www.indianpediatrics.net/nov2013/1033.pdf newer antiepileptic drugs]</ref>
==[[levetiracetam XR|Extended release]]==
==[[levetiracetam XR|Extended release]]==
[http://www.fda.gov/downloads/Drugs/DrugSafety/UCM312880.pdf Medication guide FDA]
[http://www.fda.gov/downloads/Drugs/DrugSafety/UCM312880.pdf Medication guide FDA]
==Links==
==Links==
In myoclonic astatic epilepsy should be used with caution in children<ref>Paradoxical exacerbation of myoclonic-astatic seizures by levetiracetam in myoclonic astatic epilepsy. BMC paediatrics 15 6</ref>
Li XC et al. 2017 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609163/ Clinical characteristics and electroencephalogram analysis of levetiracetam in the treatment of children with febrile seizure recurrence]


Trinka E., et al 2015
Trinka E., et al 2015
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus] Drugs 75:1499
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus] Drugs 75:1499
 


Safraski J.-P.2015
Safraski J.-P.2015
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519029/pdf/i1535-7511-15-2-94.pdf Is There Equipoise Between Phenytoin and Levetiracetam for Seizure Prevention in Traumatic Brain Injury?]
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519029/pdf/i1535-7511-15-2-94.pdf Is There Equipoise Between Phenytoin and Levetiracetam for Seizure Prevention in Traumatic Brain Injury?]
Vrielynck P.
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716601/pdf/ndt-9-963.pdf Current and emerging treatments for absence seizures in young patients]


Jackson J.-L. et al.2015
Jackson J.-L. et al.2015
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501738/ A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache]
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501738/ A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache]
[[File:Wikidata-logo-en.svg.png|32px]]
 
Caviness J. N.
[http://www.ncbi.nlm.nih.gov/pubmed/24037428 Treatment of myoclonus]
 
deWolfe & Szafarski
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750522/pdf/fneur-04-00121.pdf Levetiracetam use in the critical care setting]
 
 
Lin CH
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672008/pdf/1471-2377-13-48.pdf Levetiracetam in the Treatment of Epileptic Seizures After Liver Transplantation]
 
[https://karmel.miraheze.org/wiki/Levetiracetam Levetiracetam] karmel(es)
 
==[[ATC]]==
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5
|colspan=2| <center>
: [[wikipedia:levetiracetam|levetiracetam]]
<ref>http://www.whocc.no/atc_ddd_index/?code=N03AX14&showdescription=yes</ref></center>
|}
 
==[[West's syndrome|West syndrome]]==
 
 
Mangano S et al.
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672008/pdf/1471-2377-13-48.pdf West syndrome followed by juvenile myoclonic epilepsy: a coincidental occurrence?]
 
 
{{refs}}
 
{{Wikidata|Q417227}}
 
[[nl:levetiracetam]]
[[Category:Anticonvulsants]]
[[Category:Anticonvulsants]]

Latest revision as of 20:29, 20 March 2023

(S)-2-(2-Oxopyrrolidin-1-yl)butanamide is an anticonvulsant medication used to treat epilepsy. It is the S-enantiomer of etiracetam, structurally similar to the prototypical nootropic drug piracetam.

Levetiracetam inhibits high-voltage-activated calcium channels and reduces calcium release from intraneural stores[1]

Extended release

Medication guide FDA

Links

In myoclonic astatic epilepsy should be used with caution in children[2]

Li XC et al. 2017 Clinical characteristics and electroencephalogram analysis of levetiracetam in the treatment of children with febrile seizure recurrence

Trinka E., et al 2015 Pharmacotherapy for Status Epilepticus Drugs 75:1499


Safraski J.-P.2015

Vrielynck P. Current and emerging treatments for absence seizures in young patients

Jackson J.-L. et al.2015

Caviness J. N. Treatment of myoclonus

deWolfe & Szafarski Levetiracetam use in the critical care setting


Lin CH Levetiracetam in the Treatment of Epileptic Seizures After Liver Transplantation

Levetiracetam karmel(es)

ATC

levetiracetam
[3]

West syndrome

Mangano S et al. West syndrome followed by juvenile myoclonic epilepsy: a coincidental occurrence?


References

References:
  1. newer antiepileptic drugs
  2. Paradoxical exacerbation of myoclonic-astatic seizures by levetiracetam in myoclonic astatic epilepsy. BMC paediatrics 15 6
  3. http://www.whocc.no/atc_ddd_index/?code=N03AX14&showdescription=yes

Q417227 at Wikidata  Interwiki via Wikidata