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Kindling model
Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly.[1] The kindling model was first proposed in the late 1960s by Goddard and colleagues.[2] Although kindling is a widely used model, its applicability to human epilepsy is controversial.[1]
Method
The word kindling is a metaphor: the increase in response to small stimuli is similar to the way small burning twigs can produce a large fire.[3] It is used by scientists to study the effects of repeated seizures on the brain.[1] A seizure may increase the likelihood that more seizures will occur; an old saying in epilepsy research is "seizures beget seizures".[1] Repeated stimulation "lowers the threshold" for more seizures to occur.Cite error: Closing </ref> missing for <ref> tag
- ↑ 1.0 1.1 1.2 1.3 Bertram E (2007). "The relevance of kindling for human epilepsy". Epilepsia 48 (Supplement 2): 65–74. doi:10.1111/j.1528-1167.2007.01068.x. PMID 17571354.
- ↑ Sato M (2008). "Kindling: An experimental model of epilepsy" (PDF). Psychiatry and Clinical Neurosciences 36 (4): 440–441. doi:10.1111/j.1440-1819.1982.tb03123.x. http://www3.interscience.wiley.com/cgi-bin/fulltext/120156204/PDFSTART.
- ↑ Abel MS, McCandless DW (1992). "The kindling model of epilepsy". in Adams RN, Baker GB, Baker JM, Bateson AN, Boisvert DPJ, Boulton AA. Neuromethods: Animal Models of Neurological Disease. Totowa, NJ: Humana Press. pp. 153–155. ISBN 0-89603-211-6.