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Kindling model: Difference between revisions

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==Method==
==Method==


The word ''kindling'' is a metaphor: the increase in response to small stimuli is similar to the way small burning twigs can produce a large fire.<ref name="Abel92">{{cite book |chapter=The kindling model of epilepsy |author=Abel MS, McCandless DW |editor=Adams RN, Baker GB, Baker JM, Bateson AN, Boisvert DPJ, Boulton AA|title=Neuromethods: Animal Models of Neurological Disease |publisher=Humana Press |location=Totowa, NJ |year=1992 |pages=153&ndash;155 |isbn=0-89603-211-6 |display-editors=etal}}
The word ''kindling'' is a metaphor: the increase in response to small stimuli is similar to the way small burning twigs can produce a large fire. It is used by scientists to study the effects of repeated seizures on the brain. A seizure may increase the likelihood that more seizures will occur; an old saying in epilepsy research is "seizures beget seizures".
</ref> It is used by scientists to study the effects of repeated seizures on the brain.<ref name="Bertram07"/>  A seizure may increase the likelihood that more seizures will occur; an old saying in epilepsy research is "seizures beget seizures".<ref name="Bertram07"/>  Repeated stimulation "lowers the threshold" for more seizures to occur.<ref name=Sahoo07>{{cite journal|title=The pathophysiology of post traumatic epilepsy|author=PK Sahoo, KI Mathai, GV Ramdas, MN Swamy |journal=Indian Journal of Neurotrauma|volume=4| issue=1 |pages=11–14|year=2007 |url=http://www.ijntonline.com/June07/abstracts/03.PDF|format=PDF |doi=10.1016/s0973-0508(07)80004-9}}
 
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{{
cite journal |author=Temkin NR, Jarell AD, Anderson GD |title=Antiepileptogenic agents: how close are we? |journal=Drugs |volume=61 |issue=8 |pages=1045–55 |year=2001 |pmid=11465868 |doi=10.2165/00003495-200161080-00002
cite journal |author=Temkin NR, Jarell AD, Anderson GD |title=Antiepileptogenic agents: how close are we? |journal=Drugs |volume=61 |issue=8 |pages=1045–55 |year=2001 |pmid=11465868 |doi=10.2165/00003495-200161080-00002

Revision as of 19:26, 4 November 2015

Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly.[1] The kindling model was first proposed in the late 1960s by Goddard and colleagues.[2] Although kindling is a widely used model, its applicability to human epilepsy is controversial.[1]

Method

The word kindling is a metaphor: the increase in response to small stimuli is similar to the way small burning twigs can produce a large fire. It is used by scientists to study the effects of repeated seizures on the brain. A seizure may increase the likelihood that more seizures will occur; an old saying in epilepsy research is "seizures beget seizures".

Temkin NR, Jarell AD, Anderson GD (2001). "Antiepileptogenic agents: how close are we?". Drugs 61 (8): 1045–55. doi:10.2165/00003495-200161080-00002. PMID 11465868. 

[3]

  1. ↑ 1.0 1.1 Bertram E (2007). "The relevance of kindling for human epilepsy". Epilepsia 48 (Supplement 2): 65–74. doi:10.1111/j.1528-1167.2007.01068.x. PMID 17571354. 
  2. ↑ Sato M (2008). "Kindling: An experimental model of epilepsy" (PDF). Psychiatry and Clinical Neurosciences 36 (4): 440–441. doi:10.1111/j.1440-1819.1982.tb03123.x. http://www3.interscience.wiley.com/cgi-bin/fulltext/120156204/PDFSTART. 
  3. ↑ https://en.wikipedia.org/w/index.php?title=Kindling_model&oldid=678938901
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