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A pathogenesis not jet elucidated of Pyridoxine-dependent epilepsy.  The interaction of piperedeine-6-carboxylate with pyridoxal-phosphate through Knoevenagel reaction forming a complex, and the clinical responde of treatment with pyridoxine has resulted in the suggestion of central pyridoxine deficiency state.
Gospe SM Jr. Pyridoxine-dependent epilepsy
Renata Oliveira et al.2013 Pyridoxine-dependent epilepsy due to antiquitin deficiency: achieving a favourable outcome
Pirzadeh Z, Ghofrani M, Mollamohammadi M. 2017 Plasma Pyridoxal 5´-Phosphate Level in Children with Intractable and Controlled Epilepsy Iran J Child Neurol. 11(2):31-36.
Sharma S and AN Prazad 2017 inborn errors of metabolism and epilepsy:Current understanding, diagnosis, and treatment appraches
Scharer G. 2010 The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1 J Inherit Metab dis 33(5):575 585