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Lennox-Gastaut syndrome: Difference between revisions

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'''Lennox–Gastaut syndrome''' (LGS) is a difficult-to-treat form of childhood-onset [[epilepsy]] that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5&nbsp;Hz slow spike wave activity,<ref>[https://en.wikipedia.org/w/index.php?title=Lennox%E2%80%93Gastaut_syndrome&oldid=699385431 wikipedia]</ref>
'''Lennox–Gastaut syndrome''' (LGS<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214194/ Conceptualizing Lennox–Gastaut Syndrome as a Secondary Network Epilepsy]</ref>) is a difficult-to-treat form of childhood-onset [[epilepsy]] that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5&nbsp;Hz slow spike wave activity,<ref>[https://en.wikipedia.org/w/index.php?title=Lennox%E2%80%93Gastaut_syndrome&oldid=699385431 wikipedia]</ref>


LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489077/ Relationship of Lennox-Gastaut syndrome with perinatal event: A cross-sectional study]</ref>
LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489077/ Relationship of Lennox-Gastaut syndrome with perinatal event: A cross-sectional study]</ref>


==Links==
==Links==
<small>LGS may evolve from [[West's syndrome|West syndrome]]</small>


[http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2015;volume=63;issue=4;spage=571;epage=582;aulast=Chandra Endoscopic epilepsy surgery: Emergence of a new procedure]
[http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2015;volume=63;issue=4;spage=571;epage=582;aulast=Chandra Endoscopic epilepsy surgery: Emergence of a new procedure]
[http://onlinelibrary.wiley.com/doi/10.1111/epi.12567/full Lennox-Gastaut syndrome: A consensus approach to differential diagnosis] epilepsia 55(4):4-9 (2014)
[http://onlinelibrary.wiley.com/doi/10.1111/epi.12742/epdf Surgical options for patients with Lennox-Gastaut syndrom] epilepsia suppl. 55:21 4:21-8. doi: 10.1111/epi.12742.
*[[epileptic encephalopathy]]


==[[Rufinamide]]==
==[[Rufinamide]]==
[http://www.ejpn-journal.com/article/S1090-3798(16)00004-0/abstract Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study]
[http://www.ejpn-journal.com/article/S1090-3798(16)00004-0/abstract Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study]
==Clobazam==
==Clobazam==
[[Clobazam]] was approved by FDA on 2011 as adjuntive treatment of seisures associated with LGS in patients 2 year and older
 
[[File:Fneur-05-00225-g001.jpg|thumb|Archer et al. Ictal EEG features and peri-ictal SPECT of tonic seizures in LGS. Frontiers in Neurology 5 2014]]
[[Clobazam]] was approved by FDA on 2011 as adjuntive treatment of seizures associated with LGS in patients 2 year and older
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467745/pdf/tcrm-11-905.pdf Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome]</ref>
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467745/pdf/tcrm-11-905.pdf Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome]</ref>


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[http://onlinelibrary.wiley.com/doi/10.1111/epi.12561/epdf stable dosage of clobazam for LGS are associated Epilepsia 55: 558(2014)]
[http://onlinelibrary.wiley.com/doi/10.1111/epi.12561/epdf stable dosage of clobazam for LGS are associated Epilepsia 55: 558(2014)]
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508372/ Use and cost comparison of clobazam to other antiepileptic drugs for treatment of Lennox-Gastaut syndrome]
[http://www.epilepsybehavior.com/article/S1525-5050(17)30286-X/fulltext Assessment of treatment patterns and healthcare costs associated with probable Lennox–Gastaut syndrome]


{{disease|G40.7|Lennox-Gastaut syndrome}}
{{disease|G40.7|Lennox-Gastaut syndrome}}


{{Wikidata|Q1544884}}
{{Wikidata|Q1544884}}
<references/>
{{refs}}
 
[[nl:Syndroom van Lennox-Gastaut]]
[[Category:Medicine]]
[[Category:disease]]
[[Category:disease]]

Latest revision as of 23:06, 29 January 2023

Lennox–Gastaut syndrome (LGS[1]) is a difficult-to-treat form of childhood-onset epilepsy that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5 Hz slow spike wave activity,[2]

LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures[3]

Links

LGS may evolve from West syndrome

Endoscopic epilepsy surgery: Emergence of a new procedure

Lennox-Gastaut syndrome: A consensus approach to differential diagnosis epilepsia 55(4):4-9 (2014)

Surgical options for patients with Lennox-Gastaut syndrom epilepsia suppl. 55:21 4:21-8. doi: 10.1111/epi.12742.


Rufinamide

Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study

Clobazam

Archer et al. Ictal EEG features and peri-ictal SPECT of tonic seizures in LGS. Frontiers in Neurology 5 2014

Clobazam was approved by FDA on 2011 as adjuntive treatment of seizures associated with LGS in patients 2 year and older [4]

Clobazam is equally safe and efficacious for seizures associated with Lennox–Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results

stable dosage of clobazam for LGS are associated Epilepsia 55: 558(2014)

Use and cost comparison of clobazam to other antiepileptic drugs for treatment of Lennox-Gastaut syndrome

Assessment of treatment patterns and healthcare costs associated with probable Lennox–Gastaut syndrome

Disease classification WHO
G40.7 Lennox-Gastaut syndrome

Q1544884 at Wikidata  Interwiki via Wikidata

References

References: