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Valproate XR

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improved compliance was observed with valproic acid and divalproex sodium[1] The patients had significantly less lateral effects (e.g. headaches, tremor of hands, and gastric upset and aggression were less) [2]

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Leppik & Hovinga Extended-release antiepileptic drugs: a comparison of pharmacokinetic parameters relative to original immediate-release formulations epilepsia 54(2013)

  1. ↑ Extended-Release Formulations of antiepileptic drug: Rationale and comparative value
  2. ↑ Immediate switching from a chrono to an extended-release formulation of divalproex sodium: A two-part study in patients with controlled epilepsy
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