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Valproate: Difference between revisions
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Valproic acid is a carboxylic acid, a well probed [[Antiepileptic drug|AED]]<ref>[http://www.ncbi.nlm.nih.gov/pubmed/26608980 Long-term Effectiveness of Antiepileptic Drug Monotherapy in Partial Epileptic Patients: A 7-year Study in an Epilepsy Center in China]</ref>, with a high teratogenic potential.<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892321/pdf/BCN-7-165.pdf Hallervorden-Spatz Syndrome with Seizures ]</ref> <ref>[http://www.tijdschriftvoorpsychiatrie.nl/assets/articles/58-2016-3-artikel-solignac.pdf Een meisje met foetaal valproaatsyndroom en autismespectrumstoornis ]</ref> | Valproic acid is a carboxylic acid, a well probed [[Antiepileptic drug|AED]]<ref>[http://www.ncbi.nlm.nih.gov/pubmed/26608980 Long-term Effectiveness of Antiepileptic Drug Monotherapy in Partial Epileptic Patients: A 7-year Study in an Epilepsy Center in China]</ref>, with a high teratogenic potential.<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892321/pdf/BCN-7-165.pdf Hallervorden-Spatz Syndrome with Seizures ]</ref> <ref>[http://www.tijdschriftvoorpsychiatrie.nl/assets/articles/58-2016-3-artikel-solignac.pdf Een meisje met foetaal valproaatsyndroom en autismespectrumstoornis ]</ref> | ||
<ref>[http://www.psychiatrist.com/JCP/article/_layouts/ppp.psych.controls/BinaryViewer.ashx?Article=/JCP/article/Pages/2016/v77n04/v77n0420.aspx&Type=Article Should women in childbearing potential be prescribed valproate?]</ref>, | <ref>[http://www.psychiatrist.com/JCP/article/_layouts/ppp.psych.controls/BinaryViewer.ashx?Article=/JCP/article/Pages/2016/v77n04/v77n0420.aspx&Type=Article Should women in childbearing potential be prescribed valproate?]</ref>, | ||
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erithema nodosum was observed associated with valproate therapy | erithema nodosum was observed associated with valproate therapy | ||
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695434/pdf/ad-27-765.pdf Erythema Nodosum Associated with Valproate ]</ref> | <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695434/pdf/ad-27-765.pdf Erythema Nodosum Associated with Valproate ]</ref> | ||
==Links== | ==Links== | ||
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<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623793/pdf/epj-07-1344.pdf Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial]</ref> | <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623793/pdf/epj-07-1344.pdf Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial]</ref> | ||
==ATC== | |||
http://www.whocc.no/atc_ddd_index/?code=N03AX11 | |||
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5 | {| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5 | ||
|colspan=2| <center> | |colspan=2| <center><gallery>File:Valproic acid.svg.png</gallery> | ||
: [[wikipedia:valproate|valproate]] | : [[wikipedia:valproate|valproate]] | ||
<ref>http://www.whocc.no/atc_ddd_index/?code=N03AG01</ref></center> | <ref>http://www.whocc.no/atc_ddd_index/?code=N03AG01</ref></center> | ||
|} | |} | ||
==extended release== | ==[[Valproate XR|extended release]]== | ||
https://www.drugs.com/pro/divalproex-extended-release.html | https://www.drugs.com/pro/divalproex-extended-release.html | ||
{{refs}} | |||
{{Wikidata|Q240642}} | |||
[[Category:Epilepsy]] | [[Category:Epilepsy]] | ||
[[Category:Anticonvulsants]] | |||
Latest revision as of 22:47, 18 May 2019
Valproic acid is a carboxylic acid, a well probed AED[1], with a high teratogenic potential.[2] [3] [4],
may alter bone metabolism
[5] erithema nodosum was observed associated with valproate therapy [6]
Links
Fanconi syndrome
Progressive myoclonic epilepsy with Fanconi syndrome
Autism
Hipothyroidism
Hypothyroidism may exacerbate valproate-related hyperammonemic delirium
Vitamin B2
ATC
http://www.whocc.no/atc_ddd_index/?code=N03AX11
extended release
https://www.drugs.com/pro/divalproex-extended-release.html
