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Phenytoin
Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures;
with lower bone health disturbances[1][2] higher dosis of the drug enhances the risk of hepatocellular carcinoma [3]
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recomended[4]
alteration of CyP450 may conduce to thyroid hormone function disturbances (observed phenobarbitone, carbamazepine) [5]
Persistence
ATC
https://www.whocc.no/atc_ddd_index/?code=N03AB02
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084542/
- ↑ The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism
- ↑ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study
- ↑ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations
- ↑ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study