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Phenytoin: Difference between revisions

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<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102649/ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study]</ref>
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102649/ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study]</ref>
   
   
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recomended<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020771/ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations]</ref>
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recommended<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020771/ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations]</ref>


alteration of CyP450 may conduce to thyroid hormone function disturbances (observed [[phenobarbitone]], [[carbamazepine]])
alteration of CyP450 may conduce to thyroid hormone function disturbances (observed [[phenobarbitone]], [[carbamazepine]])
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966235/ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study]
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966235/ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study]</ref>
==Persistence==
==Persistence==


[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008541/ Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.]
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008541/ Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.]


==ATC==
==Warfarin==
https://www.whocc.no/atc_ddd_index/?code=N03AB02
 
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936086/ Warfarin and phenytoin drug interaction with possible purple glove syndrome]
==[[Rhabdomyolysis]]==
 
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933680/ A Case of Phenytoin-induced Rhabdomyolysis in Status Epilepticus]
 
==Psychosis==
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721166/ Psychosis as Harbinger of Phenytoin Toxicity]
 
==Medicinal Chemistry==
 
[https://www.ncbi.nlm.nih.gov/pubmed/8681892 Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.]
 
==[[ATC]]==
[https://www.whocc.no/atc_ddd_index/?code=N03AB02 N03AB02]
{{wikidata|Q410400}}
<references/>
<references/>
[[Category:Anticonvulsants]]
[[Category:Anticonvulsants]]

Latest revision as of 01:09, 20 August 2019

Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures;

with lower bone health disturbances[1][2] higher dosis of the drug enhances the risk of hepatocellular carcinoma [3]

Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recommended[4]

alteration of CyP450 may conduce to thyroid hormone function disturbances (observed phenobarbitone, carbamazepine) [5]

Persistence

Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.

Warfarin

Warfarin and phenytoin drug interaction with possible purple glove syndrome

Rhabdomyolysis

A Case of Phenytoin-induced Rhabdomyolysis in Status Epilepticus

Psychosis

Psychosis as Harbinger of Phenytoin Toxicity

Medicinal Chemistry

Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.

ATC

N03AB02 Q410400 at Wikidata  Interwiki via Wikidata