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Lennox-Gastaut syndrome: Difference between revisions

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[http://www.ejpn-journal.com/article/S1090-3798(16)00004-0/abstract Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study]
[http://www.ejpn-journal.com/article/S1090-3798(16)00004-0/abstract Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study]
==Clobazam==
==Clobazam==
[[File:Fneur-05-00225-g001.jpg|thumb|ARCHER ET AL.Ictal EEG features and peri-ictal SPECT of tonic seizures in LGS]]
[[Clobazam]] was approved by FDA on 2011 as adjuntive treatment of seisures associated with LGS in patients 2 year and older
[[Clobazam]] was approved by FDA on 2011 as adjuntive treatment of seisures associated with LGS in patients 2 year and older
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467745/pdf/tcrm-11-905.pdf Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome]</ref>
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467745/pdf/tcrm-11-905.pdf Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome]</ref>

Revision as of 22:13, 31 January 2016

Lennox–Gastaut syndrome (LGS[1]) is a difficult-to-treat form of childhood-onset epilepsy that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5 Hz slow spike wave activity,[2]

LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures[3]

Links

Endoscopic epilepsy surgery: Emergence of a new procedure

Rufinamide

Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study

Clobazam

ARCHER ET AL.Ictal EEG features and peri-ictal SPECT of tonic seizures in LGS

Clobazam was approved by FDA on 2011 as adjuntive treatment of seisures associated with LGS in patients 2 year and older [4]

Clobazam is equally safe and efficacious for seizures associated with Lennox–Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results

stable dosage of clobazam for LGS are associated Epilepsia 55: 558(2014)

Disease classification WHO
G40.7 Lennox-Gastaut syndrome

Q1544884 at Wikidata  Interwiki via Wikidata