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Lamotrigine: Difference between revisions
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Lamotrigine an [[antiepileptic drug|AED]] and antidepressant | Lamotrigine is an [[antiepileptic drug|AED]] and antidepressant | ||
effective in [[epilepsy|focal epilepsies]], such as rolandic epilepsy | effective in [[epilepsy|focal epilepsies]], such as rolandic epilepsy. | ||
<ref>[http://ugeskriftet.dk/videnskab/atypisk-femurfraktur-hos-en-kvinde-i-behandling-med-lamotrigen ugeskriftet]</ref> | <ref>[http://ugeskriftet.dk/videnskab/atypisk-femurfraktur-hos-en-kvinde-i-behandling-med-lamotrigen ugeskriftet]</ref>Lamotrigine has also been found effective in the treatment of bipolar disorder being more efficacious in treating the depressive phase of the illness. The exact mechanism by which lamotrigine acts as a mood stabilizer remains unclear<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615936/pdf/fphar-06-00242.pdf Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer]</ref> | ||
Lamotrigine inhibits the voltage-gated sodium and calcium channels<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791905/ A Randomized Double-Blind Placebo-Controlled Study to Compare Preemptive Analgesic Efficacy of Novel Antiepileptic Agent Lamotrigine in Patients Undergoing Major Surgeries]</ref> | Lamotrigine inhibits the voltage-gated sodium and calcium channels<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791905/ A Randomized Double-Blind Placebo-Controlled Study to Compare Preemptive Analgesic Efficacy of Novel Antiepileptic Agent Lamotrigine in Patients Undergoing Major Surgeries]</ref> | ||
Rhabdomyolisis has been reported in a case of bipolar disorder by overdose of the lamotrigine | Rhabdomyolisis has been reported in a case of bipolar disorder by overdose of the lamotrigine | ||
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==Links== | ==Links== | ||
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791905/ A Randomized Double-Blind Placebo-Controlled Study to Compare Preemptive Analgesic Efficacy of Novel Antiepileptic Agent Lamotrigine in Patients Undergoing Major Surgeries] | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791905/ A Randomized Double-Blind Placebo-Controlled Study to Compare Preemptive Analgesic Efficacy of Novel Antiepileptic Agent Lamotrigine in Patients Undergoing Major Surgeries] | ||
[https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0041-108911.pdf Neurologische Erkrankungen und Schwangerschaft –eine Übersicht] | *[https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0041-108911.pdf Neurologische Erkrankungen und Schwangerschaft –eine Übersicht] | ||
<references/> | <references/> | ||
Revision as of 14:49, 16 April 2016
Lamotrigine is an AED and antidepressant effective in focal epilepsies, such as rolandic epilepsy. [1]Lamotrigine has also been found effective in the treatment of bipolar disorder being more efficacious in treating the depressive phase of the illness. The exact mechanism by which lamotrigine acts as a mood stabilizer remains unclear[2] Lamotrigine inhibits the voltage-gated sodium and calcium channels[3] Rhabdomyolisis has been reported in a case of bipolar disorder by overdose of the lamotrigine [4]
Links
- ↑ ugeskriftet
- ↑ Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer
- ↑ A Randomized Double-Blind Placebo-Controlled Study to Compare Preemptive Analgesic Efficacy of Novel Antiepileptic Agent Lamotrigine in Patients Undergoing Major Surgeries
- ↑ Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature