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Lamotrigine: Difference between revisions
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<ref>[http://ugeskriftet.dk/videnskab/atypisk-femurfraktur-hos-en-kvinde-i-behandling-med-lamotrigen ugeskriftet]</ref>Lamotrigine has also been found effective in the treatment of bipolar disorder being more efficacious in treating the depressive phase of the illness. The exact mechanism by which lamotrigine acts as a mood stabilizer remains unclear<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615936/pdf/fphar-06-00242.pdf Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer]</ref> | <ref>[http://ugeskriftet.dk/videnskab/atypisk-femurfraktur-hos-en-kvinde-i-behandling-med-lamotrigen ugeskriftet]</ref>Lamotrigine has also been found effective in the treatment of bipolar disorder being more efficacious in treating the depressive phase of the illness. The exact mechanism by which lamotrigine acts as a mood stabilizer remains unclear<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615936/pdf/fphar-06-00242.pdf Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer]</ref> | ||
Lamotrigine inhibits the voltage-gated sodium and calcium channels<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791905/ A Randomized Double-Blind Placebo-Controlled Study to Compare Preemptive Analgesic Efficacy of Novel Antiepileptic Agent Lamotrigine in Patients Undergoing Major Surgeries]</ref> | Lamotrigine inhibits the voltage-gated sodium and calcium channels<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791905/ A Randomized Double-Blind Placebo-Controlled Study to Compare Preemptive Analgesic Efficacy of Novel Antiepileptic Agent Lamotrigine in Patients Undergoing Major Surgeries]</ref> | ||
Rhabdomyolysis has been reported in a case of bipolar disorder by overdose of the lamotrigine | [[Rhabdomyolysis]] has been reported in a case of bipolar disorder by overdose of the lamotrigine | ||
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765213/ Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature]</ref> | <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765213/ Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature]</ref> | ||
==ATC== | ==ATC== | ||
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[[File:Lamotrigine_ball-and-stick_model.png|50px]] | [[File:Lamotrigine_ball-and-stick_model.png|50px]] | ||
: [[wikipedia:lamotrigine|lamotrigine]] | : [[wikipedia:lamotrigine|lamotrigine]] | ||
<ref>[https://www.whocc.no/atc_ddd_index/?code=N03AX09 | <ref>[https://www.whocc.no/atc_ddd_index/?code=N03AX09 N03AX09]</ref></center> | ||
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==Links== | ==Links== | ||
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*[https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0041-108911.pdf Neurologische Erkrankungen und Schwangerschaft –eine Übersicht] | *[https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0041-108911.pdf Neurologische Erkrankungen und Schwangerschaft –eine Übersicht] | ||
{{wikidata|Q410346}} | |||
{{refs}} | |||
[[Category:anticonvulsants]] | [[Category:anticonvulsants]] | ||
Latest revision as of 23:28, 29 January 2023
Lamotrigine is an AED and antidepressant effective in focal epilepsies, such as rolandic epilepsy. [1]Lamotrigine has also been found effective in the treatment of bipolar disorder being more efficacious in treating the depressive phase of the illness. The exact mechanism by which lamotrigine acts as a mood stabilizer remains unclear[2] Lamotrigine inhibits the voltage-gated sodium and calcium channels[3] Rhabdomyolysis has been reported in a case of bipolar disorder by overdose of the lamotrigine [4]
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