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Cannabis (drug): Difference between revisions

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<small>unknown efficacy in epilepsy</small><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068473/pdf/ndt-12-2605.pdf</ref>
<small>unknown efficacy in [[epilepsy]] </small>
The Cannabis sativa plant contains more than 400 compounds, of which 100 are known as phytocannabinoids. The two cannabinoids with the highest concentrations in cannabis are delta9-tetrahydrocannabinol (Δ9-THC), responsible for most of the psychotomimetic effects of the drug, and cannabidiol (CBD), the most common non-psychoactive cannabinoid  
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068473/pdf/ndt-12-2605.pdf Managing drug-resistant epilepsy: challenges and solutions]</ref>
<ref>Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol</ref>
<ref>[https://www.ncbi.nlm.nih.gov/pubmed/26941559 Is the medical use of cannabis a therapeutic option for children?]</ref>
 
The Cannabis sativa plant contains(<ref>http://www.agriculture.pa.gov/Protect/PlantIndustry/NIPPP/Documents/marijuana%20article.pdf</ref>) more than 400 compounds, of which 100 are known as phytocannabinoids. The two cannabinoids with the highest concentrations in cannabis are delta9-tetrahydrocannabinol (Δ9-THC), responsible for most of the psychotomimetic effects of the drug, and cannabidiol ([[Epidiolex|CBD]]), the most common non-psychoactive cannabinoid  
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043219/ Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol]</ref>
 
==Links==
[https://www.ncbi.nlm.nih.gov/pubmed/26835389 Cannabinoids for pediatric epilepsy? Up in smoke or real science?]
===Medical Cannabis===
Kolikonda et al. 2016
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911937/pdf/icns_13_3-4_23.pdf Medical Cannabis for epilepsy Innovations clin.neurosci 13(3-4):]</ref>
===Entourage effect===
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604191/ Cannabinoids and Epilepsy]
 
Ben Shabat et al 1998. [https://www.ncbi.nlm.nih.gov/pubmed/9721036 An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity Eur J Pharmacol.]
 


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Latest revision as of 14:05, 11 July 2018