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<ref>[http://www.epires-journal.com/article/S0920-1211(14)00228-9/pdf  
<ref>[http://www.epires-journal.com/article/S0920-1211(14)00228-9/pdf  
Rufinamide as an adjunctive therapy for Lennox-Gastaut syndrome: a randomized double-blind placebo-controlled trial in Japan]</ref>(cf. Alssad et Coren 2014) <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256616/pdf/bcp0078-1264.pdf Exposure to rufinamide and risks of CNS adverse events in drug-resistant epilepsy: a meta-analysis of randomized, placebo-controlled trials] </ref>
Rufinamide as an adjunctive therapy for Lennox-Gastaut syndrome: a randomized double-blind placebo-controlled trial in Japan]</ref>(cf. Alssad et Coren 2014) <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256616/pdf/bcp0078-1264.pdf Exposure to rufinamide and risks of CNS adverse events in drug-resistant epilepsy: a meta-analysis of randomized, placebo-controlled trials] </ref>
<small>"Rufinamide received the status of orphan drug for [[epilepsy]] in 2004 in Europe"</small>
<ref>[http://onlinelibrary.wiley.com/doi/10.1111/epi.12689/epdf
Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience]</ref>
<references/>
<references/>
{{Wikidata|Q408565}}
{{Wikidata|Q408565}}


[[Category:Anticonvulsants]]
[[Category:Anticonvulsants]]

Revision as of 23:24, 27 January 2016

Lennox-Gastaut is a low prevalence epileptic syndrome (1:10000), and Cochrane Epilepsy Group concluded that treatment remain unconcluside Otsuka et al (2014) state efficacious and well tolerated AED [1](cf. Alssad et Coren 2014) [2] "Rufinamide received the status of orphan drug for epilepsy in 2004 in Europe" [3]

  1. [http://www.epires-journal.com/article/S0920-1211(14)00228-9/pdf Rufinamide as an adjunctive therapy for Lennox-Gastaut syndrome: a randomized double-blind placebo-controlled trial in Japan]
  2. Exposure to rufinamide and risks of CNS adverse events in drug-resistant epilepsy: a meta-analysis of randomized, placebo-controlled trials
  3. [http://onlinelibrary.wiley.com/doi/10.1111/epi.12689/epdf Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience]

Q408565 at Wikidata  Interwiki via Wikidata