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Carbamazepine

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structure related to imipramin

can form five polymorphic states, with low water solubility [1] spina bifida

Stevens-Johnson syndrome[2]

Links

Spray drying as a reliable route to produce metastable carbamazepine form IV

Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes

Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine

The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine

Extended release

[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279715/pdf/nihms614995.pdf The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder]

  1. ↑ Halliwell RA, Bhardwaj RM, Brown C, Briggs NEB, Dunn J, Robertson J,Nordon A, Florence AJ, Spray drying as a reliable route to produce metastable carbamazepine form IV, Journal of Pharmaceutical Sciences (2017), doi: 10.1016/j.xphs.2017.03.045.
  2. ↑ HLA-B*15:21 and carbamazepine-induced Stevens-Johnson syndrome: pooled-data and in silico analysis.
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