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Primidone

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Primidone is an anticonvulsant that is metabolized to phenylethylmalonamide (PEMA) and phenobarbital[1], historical considered a prodrug of phenobarbital, nevertheless it is superior against tremor [2] [3] Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner

ATC

http://www.whocc.no/atc_ddd_index/?code=N03AA03 [4]

Links

Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs

Factors Associated with Ordering Laboratory Monitoring of High-Risk Medications

Notes

  1. ↑ http://www.neurology.org/content/64/12/2008.full.pdf+html Practice Parameter:Therapies for essential tremor Report of the Quality Standards Subcommittee of the American Academy of Neurology
  2. ↑ Essential Tremor: What We Can Learn from Current Pharmacotherapy
  3. ↑ Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors
  4. ↑ Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner
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