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Valproate

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Valproic acid is a carboxylic acid, a well probed AED[1], with a high teratogenic potential.[2] [3] [4],

may alter bone metabolism

[5] erithema nodosum was observed associated with valproate therapy [6]

ATC

http://www.whocc.no/atc_ddd_index/?code=N03AX11

Links

http://flexikon.doccheck.com/de/Valproins%C3%A4ure?utm_source=www.doccheck.flexikon&utm_medium=web&utm_campaign=DC%2BSearch

Fanconi syndrome

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900196/pdf/10.1177_2054270415623145.pdf Progressive myoclonic epilepsy with Fanconi syndrome

Autism

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893673/pdf/srep27400.pdf Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure

Hipothyroidism

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864769/pdf/40681_2016_Article_12.pdf Hypothyroidism may exacerbate valproate-related hyperammonemic delirium

Vitamin B2

[7]

  1. ↑ http://www.ncbi.nlm.nih.gov/pubmed/26608980 Long-term Effectiveness of Antiepileptic Drug Monotherapy in Partial Epileptic Patients: A 7-year Study in an Epilepsy Center in China
  2. ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892321/pdf/BCN-7-165.pdf Hallervorden-Spatz Syndrome with Seizures
  3. ↑ http://www.tijdschriftvoorpsychiatrie.nl/assets/articles/58-2016-3-artikel-solignac.pdf Een meisje met foetaal valproaatsyndroom en autismespectrumstoornis
  4. ↑ http://www.psychiatrist.com/JCP/article/_layouts/ppp.psych.controls/BinaryViewer.ashx?Article=/JCP/article/Pages/2016/v77n04/v77n0420.aspx&Type=Article Shpuld women in childbearing potential be prescribed valproate?
  5. ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855910/pdf/12887_2016_Article_597.pdf Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children-a medical center experience
  6. ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695434/pdf/ad-27-765.pdf Erythema Nodosum Associated with Valproate
  7. ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623793/pdf/epj-07-1344.pdf Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial
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