Midazolam

Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.^[1]

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Status epilepticus

lorazepam>diazepam^[2] ^[3] ^[4]

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midazolam

↑ Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.
↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.
↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/ Pharmacotherapy for Status Epilepticus
↑ http://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813

[1] Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.

[2] ttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.

[3] ttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/ Pharmacotherapy for Status Epilepticus

[4] ttp://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813

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Midazolam

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