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Clozapine
Cloxapine is a prodrug, nor derivative is the active drug. Clozapine has had strong mood-stabilizing properties[1] Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent[2] between rare adverse effects agranulocitosis[3][4]
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf
- ↑ http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998
- ↑ [http://www.njmonline.nl/getpdf.php?id=1609
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532211/pdf/ndt-11-1995.pdf Rare and very rare adverse effects of clozapine]