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Phenytoin

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Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures;

with lower bone health disturbances[1][2] higher dosis of the drug enhances the risk of hepatocellular carcinoma [3]

Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recomended[4]

alteration of CyP450 may conduce to thyroid hormone function disturbances (observed phenobarbitone, carbamazepine) [5]

Persistence

Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.

Warfarin

Warfarin and phenytoin drug interaction with possible purple glove syndrome

Rhabdomyolysis

A Case of Phenytoin-induced Rhabdomyolysis in Status Epilepticus

Psychosis

Psychosis as Harbinger of Phenytoin Toxicity

Medicinal Chemstry

Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.

ATC

https://www.whocc.no/atc_ddd_index/?code=N03AB02

  1. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084542/
  2. ↑ The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism
  3. ↑ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study
  4. ↑ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations
  5. ↑ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study
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