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Valproate

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Valproic acid is a carboxylic acid, a well probed AED[1], with a high teratogenic potential.[2] [3] [4],

may alter bone metabolism

[5] erithema nodosum was observed associated with valproate therapy [6]

ATC

http://www.whocc.no/atc_ddd_index/?code=N03AX11

Links

FLexikon:Valproinsäure

Fanconi syndrome

Progressive myoclonic epilepsy with Fanconi syndrome

Autism

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure

Hipothyroidism

Hypothyroidism may exacerbate valproate-related hyperammonemic delirium

Vitamin B2

[7]

  1. ↑ [http://www.ncbi.nlm.nih.gov/pubmed/26608980 Long-term Effectiveness of Antiepileptic Drug Monotherapy in Partial Epileptic Patients: A 7-year Study in an Epilepsy Center in China
  2. ↑ Hallervorden-Spatz Syndrome with Seizures
  3. ↑ Een meisje met foetaal valproaatsyndroom en autismespectrumstoornis
  4. ↑ http://www.psychiatrist.com/JCP/article/_layouts/ppp.psych.controls/BinaryViewer.ashx?Article=/JCP/article/Pages/2016/v77n04/v77n0420.aspx&Type=Article Shpuld women in childbearing potential be prescribed valproate?
  5. ↑ Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children-a medical center experience
  6. ↑ Erythema Nodosum Associated with Valproate
  7. ↑ Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial
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