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Carbamazepine

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structure related to imipraminminiature

can form five polymorphic states, with low water solubility [1]

Carbamazepine teratogenicity is relatively specific to spina bifida, though the risk is less than with valproic acid[2] [3]

Stevens-Johnson syndrome[4][5] [6]

"there is any association between sexual dysfunctions and various AEDs in the treatment, except for carbamazepine" [7]

Links

Spray drying as a reliable route to produce metastable carbamazepine form IV

Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes

Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine

The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine

Rapamycin

Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

Extended release

The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder

ATC

[8]

  1. ↑ Halliwell RA, Bhardwaj RM, Brown C, Briggs NEB, Dunn J, Robertson J,Nordon A, Florence AJ, Spray drying as a reliable route to produce metastable carbamazepine form IV, Journal of Pharmaceutical Sciences (2017), doi: 10.1016/j.xphs.2017.03.045.
  2. ↑ Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study
  3. ↑ Malformaciones congenitas en hijos de madres epilépticas con y sin tratamiento con anticonvulsivantes
  4. ↑ HLA-B*15:21 and carbamazepine-induced Stevens-Johnson syndrome: pooled-data and in silico analysis.
  5. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296452/ Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case
  6. ↑ https://www.drugs.com/monograph/carbamazepine.html
  7. ↑ Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs: a prospective study
  8. ↑ https://www.whocc.no/atc_ddd_index/?code=N03AF01
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