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Phenytoin

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Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures;

with lower bone health disturbances[1][2] higher dosis of the drug enhances the risk of hepatocellular carcinoma [3]

Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recomended[4]

Persistence

Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.

ATC

https://www.whocc.no/atc_ddd_index/?code=N03AB02

  1. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084542/
  2. ↑ The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism
  3. ↑ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study
  4. ↑ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations
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