Wikisage, the free encyclopedia of the second generation, is digital heritage
Phenytoin: Difference between revisions
| Line 24: | Line 24: | ||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721166/ Psychosis as Harbinger of Phenytoin Toxicity] | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721166/ Psychosis as Harbinger of Phenytoin Toxicity] | ||
==Medicinal | ==Medicinal Chemistry== | ||
[https://www.ncbi.nlm.nih.gov/pubmed/8681892 Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.] | [https://www.ncbi.nlm.nih.gov/pubmed/8681892 Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.] | ||
Revision as of 01:28, 12 December 2016
Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures;
with lower bone health disturbances[1][2] higher dosis of the drug enhances the risk of hepatocellular carcinoma [3]
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recomended[4]
alteration of CyP450 may conduce to thyroid hormone function disturbances (observed phenobarbitone, carbamazepine) [5]
Persistence
Warfarin
Warfarin and phenytoin drug interaction with possible purple glove syndrome
Rhabdomyolysis
A Case of Phenytoin-induced Rhabdomyolysis in Status Epilepticus
Psychosis
Psychosis as Harbinger of Phenytoin Toxicity
Medicinal Chemistry
ATC
https://www.whocc.no/atc_ddd_index/?code=N03AB02
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084542/
- ↑ The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism
- ↑ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study
- ↑ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations
- ↑ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study