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Lennox-Gastaut syndrome: Difference between revisions

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'''Lennox–Gastaut syndrome''' (LGS<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214194/</ref>) is a difficult-to-treat form of childhood-onset [[epilepsy]] that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5&nbsp;Hz slow spike wave activity,<ref>[https://en.wikipedia.org/w/index.php?title=Lennox%E2%80%93Gastaut_syndrome&oldid=699385431 wikipedia]</ref>
'''Lennox–Gastaut syndrome''' (LGS<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214194/ Conceptualizing Lennox–Gastaut Syndrome as a Secondary Network Epilepsy]</ref>) is a difficult-to-treat form of childhood-onset [[epilepsy]] that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5&nbsp;Hz slow spike wave activity,<ref>[https://en.wikipedia.org/w/index.php?title=Lennox%E2%80%93Gastaut_syndrome&oldid=699385431 wikipedia]</ref>


LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489077/ Relationship of Lennox-Gastaut syndrome with perinatal event: A cross-sectional study]</ref>
LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489077/ Relationship of Lennox-Gastaut syndrome with perinatal event: A cross-sectional study]</ref>

Revision as of 22:21, 31 January 2016

Lennox–Gastaut syndrome (LGS[1]) is a difficult-to-treat form of childhood-onset epilepsy that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5 Hz slow spike wave activity,[2]

LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures[3]

Links

Endoscopic epilepsy surgery: Emergence of a new procedure

Rufinamide

Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study

Clobazam

Archer et al. Ictal EEG features and peri-ictal SPECT of tonic seizures in LGS. Frontiers in Neurology 5 2014

Clobazam was approved by FDA on 2011 as adjuntive treatment of seisures associated with LGS in patients 2 year and older [4]

Clobazam is equally safe and efficacious for seizures associated with Lennox–Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results

stable dosage of clobazam for LGS are associated Epilepsia 55: 558(2014)

Disease classification WHO
G40.7 Lennox-Gastaut syndrome

Q1544884 at Wikidata  Interwiki via Wikidata

  1. ↑ Conceptualizing Lennox–Gastaut Syndrome as a Secondary Network Epilepsy
  2. ↑ wikipedia
  3. ↑ Relationship of Lennox-Gastaut syndrome with perinatal event: A cross-sectional study
  4. ↑ Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome
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