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Lorazepam: Difference between revisions
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[[Status epilepticus|Status epilepticus]], [[International League Against Epilepsy | | [[Status epilepticus|Status epilepticus]], [[International League Against Epilepsy |ILAE]] view as a seizure that persists for a sufficient lengh of time, maybe 5-10 (focal) minutes. | ||
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/ Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry]</ref> | <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/ Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry]</ref> | ||
Revision as of 01:59, 26 January 2016
sufficient lengh of time (viewed as 30 min.period)
Status epilepticus, ILAE view as a seizure that persists for a sufficient lengh of time, maybe 5-10 (focal) minutes.
[1]
diazepam
intravenous
Other agents
lorazepam>phenitoin
midazolam
Midazolam (or lorazepam i.v.) controls effectively 63-73% early SE[2]
clonazepam
clonazepam is more lipophylic that lorazepam, but less lipophilic than diazepam(Congdon et Forsythe epilepsia 21:97(1980))
Levetirazetam
comparison
Propofol
recruitment problem
see also Trinka et al 2015 Pharmacotherapy for Status Epilepticus Drugs 1491-1521.
