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Midazolam: Difference between revisions
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Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.<ref>Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.</ref> | Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.<ref>Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.</ref> | ||
==Weblinks== | |||
Status epilepticus | [[Status epilepticus]] | ||
== == | == == | ||
lorazepam>[[diazepam]]<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.</ref> | lorazepam>[[diazepam]]<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.</ref> | ||
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<gallery>File:Midazolam_ball-and-stick_model.png</gallery> | <gallery>File:Midazolam_ball-and-stick_model.png</gallery> | ||
==ATC== | |||
[[wikipedia:midazolam|midazolam]] | [[wikipedia:midazolam|midazolam]] | ||
<references/> | <references/> | ||
Revision as of 19:05, 23 December 2015
Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.[1]
Weblinks
ATC
- ↑ Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/ Pharmacotherapy for Status Epilepticus
- ↑ http://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813