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Midazolam: Difference between revisions
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/ Pharmacotherapy for Status Epilepticus</ref> | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/ Pharmacotherapy for Status Epilepticus</ref> | ||
<ref>http://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813</ref> | <ref>http://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813</ref> | ||
[[wikipedia:midazolam|midazolam]] | |||
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Revision as of 18:58, 23 December 2015
Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.[1]
Status epilepticus
lorazepam>diazepam[2] [3] [4] midazolam
- ↑ Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/ Pharmacotherapy for Status Epilepticus
- ↑ http://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813