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Clozapine: Difference between revisions
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Cloxapine is a prodrug, nor derivative is the active drug. Clozapine has had strong mood-stabilizing properties<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf</ref> | Cloxapine is a prodrug, nor derivative is the active drug. Clozapine is a dibenzodiazepine derivative antipsychotic, unique for its high D1 and D4 dopaminergic receptor and 5-HT2a serotonergic receptor affinity. Clozapine has had strong mood-stabilizing properties<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf</ref> | ||
Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent<ref> http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998</ref> | Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent<ref> http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998</ref> | ||
between rare adverse effects agranulocitosis, epileptiform movements<ref> http://www.njmonline.nl/getpdf.php?id=1609</ref><ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532211/pdf/ndt-11-1995.pdf Rare and very rare adverse effects of clozapine]</ref> | between rare adverse effects agranulocitosis, epileptiform movements<ref> http://www.njmonline.nl/getpdf.php?id=1609</ref><ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532211/pdf/ndt-11-1995.pdf Rare and very rare adverse effects of clozapine]</ref> | ||
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[[Category:Atipical antipsychotics]] | |||
Revision as of 19:10, 16 September 2015
Cloxapine is a prodrug, nor derivative is the active drug. Clozapine is a dibenzodiazepine derivative antipsychotic, unique for its high D1 and D4 dopaminergic receptor and 5-HT2a serotonergic receptor affinity. Clozapine has had strong mood-stabilizing properties[1] Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent[2] between rare adverse effects agranulocitosis, epileptiform movements[3][4] [5]
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf
- ↑ http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998
- ↑ http://www.njmonline.nl/getpdf.php?id=1609
- ↑ Rare and very rare adverse effects of clozapine
- ↑ Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability