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Clozapine: Difference between revisions
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Cloxapine is a prodrug, nor derivative is the active drug. Clozapine has had strong mood-stabilizing properties<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf</ref> | Cloxapine is a prodrug, nor derivative is the active drug. Clozapine has had strong mood-stabilizing properties<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf</ref> | ||
Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent<ref> http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998</ref> | Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent<ref> http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998</ref> | ||
between rare adverse effects agranulocitosis<ref> [http://www.njmonline.nl/getpdf.php?id=1609</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532211/pdf/ndt-11-1995.pdf Rare and very rare adverse effects of clozapine]</ref> | |||
<ref>http://www.njmonline.nl/getpdf.php?id=1609</ref><ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532211/pdf/ndt-11-1995.pdf Rare and very rare adverse effects of clozapine | |||
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Revision as of 18:59, 16 September 2015
Cloxapine is a prodrug, nor derivative is the active drug. Clozapine has had strong mood-stabilizing properties[1] Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent[2] between rare adverse effects agranulocitosis[3][4]
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf
- ↑ http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998
- ↑ [http://www.njmonline.nl/getpdf.php?id=1609
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532211/pdf/ndt-11-1995.pdf Rare and very rare adverse effects of clozapine]