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Clozapine: Difference between revisions
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Oke et al. 2015 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573205/ Unrecognized clozapine-related constipation leading to fatal intra-abdominal sepsis – a case report] Int Med Case Rep. J.;8:189-92. doi: 10.2147/IMCRJ.S86716. eCollection 2015. | Oke et al. 2015 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573205/ Unrecognized clozapine-related constipation leading to fatal intra-abdominal sepsis – a case report] Int Med Case Rep. J.;8:189-92. doi: 10.2147/IMCRJ.S86716. eCollection 2015. | ||
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811864/pdf/CN-7-302.pdf Mechanisms of Action of Antipsychotic Drugs of Different Classes, Refractoriness to Therapeutic Effects of Classical Neuroleptics, and Individual Variation in Sensitivity to their Actions: PART I | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811864/pdf/CN-7-302.pdf Mechanisms of Action of Antipsychotic Drugs of Different Classes, Refractoriness to Therapeutic Effects of Classical Neuroleptics, and Individual Variation in Sensitivity to their Actions: PART I] | ||
==ATC code N05== | ==ATC code N05== | ||
Revision as of 18:13, 24 November 2017
Clozapine is a prodrug, nor derivative is the active drug. Clozapine is a dibenzodiazepine derivative antipsychotic, unique for its high D1 and D4 dopaminergic receptor and 5-HT2a serotonergic receptor affinity. Clozapine has had strong mood-stabilizing properties[1] Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent[2] between rare adverse effects agranulocytosis, epileptiform movements[3][4] [5]
links
Oke et al. 2015 Unrecognized clozapine-related constipation leading to fatal intra-abdominal sepsis – a case report Int Med Case Rep. J.;8:189-92. doi: 10.2147/IMCRJ.S86716. eCollection 2015.
ATC code N05
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf
- ↑ http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998
- ↑ http://www.njmonline.nl/getpdf.php?id=1609
- ↑ Rare and very rare adverse effects of clozapine
- ↑ Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability
- ↑ http://www.whocc.no/atc_ddd_index/?code=N05AH02