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Lennox-Gastaut syndrome: Difference between revisions
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[http://www.ejpn-journal.com/article/S1090-3798(16)00004-0/abstract Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study] | [http://www.ejpn-journal.com/article/S1090-3798(16)00004-0/abstract Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study] | ||
==Clobazam== | ==Clobazam== | ||
[[Clobazam]] was approved by FDA on 2011 as adjuntive treatment of seisurez associated with LGS in patients 2 year and older | |||
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467745/pdf/tcrm-11-905.pdf Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome] | <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467745/pdf/tcrm-11-905.pdf Comprehensive overview: efficacy, tolerability, and cost-effectiveness of clobazam in Lennox-Gastaut syndrome]</ref> | ||
[http://www.epilepsybehavior.com/article/S1525-5050(15)00044-X/pdf Clobazam is equally safe and efficacious for seizures associated with Lennox–Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results] | [http://www.epilepsybehavior.com/article/S1525-5050(15)00044-X/pdf Clobazam is equally safe and efficacious for seizures associated with Lennox–Gastaut syndrome across different age groups: Post hoc analyses of short- and long-term clinical trial results] | ||
Revision as of 21:57, 31 January 2016
Lennox–Gastaut syndrome (LGS) is a difficult-to-treat form of childhood-onset epilepsy that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5 Hz slow spike wave activity,[1]
LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures[2]
Links
Endoscopic epilepsy surgery: Emergence of a new procedure
Rufinamide
Clobazam
Clobazam was approved by FDA on 2011 as adjuntive treatment of seisurez associated with LGS in patients 2 year and older [3]
Disease classification WHO
G40.7 Lennox-Gastaut syndrome
