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Clozapine: Difference between revisions
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[[File:Clozapine.svg.png|thumb]] | [[File:Clozapine.svg.png|thumb]] | ||
Cloxapine is a prodrug, nor derivative is the active drug. Clozapine is a dibenzodiazepine derivative antipsychotic, unique for its high D1 and D4 | Cloxapine is a prodrug, nor derivative is the active drug. Clozapine is a dibenzodiazepine derivative antipsychotic, unique for its high D1 and D4 dozaminergic receptor and 5-HT2a serotonergic receptor affinity. Clozapine has had strong mood-stabilizing properties<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf</ref> | ||
Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent<ref> http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998</ref> | Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent<ref> http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998</ref> | ||
between rare adverse effects | between rare adverse effects [[agranulocytosis]], [[epileptiform]] movements<ref> http://www.njmonline.nl/getpdf.php?id=1609</ref><ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532211/pdf/ndt-11-1995.pdf Rare and very rare adverse effects of clozapine]</ref> | ||
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525764/pdf/CRIPS2015-482375.pdf Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability] </ref> | <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525764/pdf/CRIPS2015-482375.pdf Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability] </ref> | ||
==ATC code N05== | ==ATC code N05== | ||
Revision as of 12:39, 26 December 2015
Cloxapine is a prodrug, nor derivative is the active drug. Clozapine is a dibenzodiazepine derivative antipsychotic, unique for its high D1 and D4 dozaminergic receptor and 5-HT2a serotonergic receptor affinity. Clozapine has had strong mood-stabilizing properties[1] Cardiovascular side effects of antipsychotic drugs include orthostatic hypotension, syncope, long QTc, ventricular tachycardia, myocarditis, cardiomyopathy, pericarditis, and sudden cardiac death, considering it is metabolized by cytochrome P450, smoking cessation could increase toxicity of the antipsychotic agent[2] between rare adverse effects agranulocytosis, epileptiform movements[3][4] [5]
ATC code N05
- ↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535045/pdf/10.1177_2045125315584871.pdf
- ↑ http://www.turkpsikiyatri.com/en/default.aspx?modul=article&id=998
- ↑ http://www.njmonline.nl/getpdf.php?id=1609
- ↑ Rare and very rare adverse effects of clozapine
- ↑ Clozapine-Induced Myocarditis: A Case Report of an Adolescent Boy with Intellectual Disability
- ↑ http://www.whocc.no/atc_ddd_index/?code=N05AH02