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Phenytoin: Difference between revisions
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<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102649/ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study]</ref> | <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102649/ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study]</ref> | ||
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly | Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recommended<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020771/ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations]</ref> | ||
alteration of CyP450 may conduce to thyroid hormone function disturbances (observed [[phenobarbitone]], [[carbamazepine]]) | alteration of CyP450 may conduce to thyroid hormone function disturbances (observed [[phenobarbitone]], [[carbamazepine]]) | ||
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[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721166/ Psychosis as Harbinger of Phenytoin Toxicity] | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721166/ Psychosis as Harbinger of Phenytoin Toxicity] | ||
==Medicinal | ==Medicinal Chemistry== | ||
[https://www.ncbi.nlm.nih.gov/pubmed/8681892 Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.] | [https://www.ncbi.nlm.nih.gov/pubmed/8681892 Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.] | ||
==ATC== | ==[[ATC]]== | ||
https://www.whocc.no/atc_ddd_index/?code=N03AB02 | [https://www.whocc.no/atc_ddd_index/?code=N03AB02 N03AB02] | ||
{{wikidata|Q410400}} | |||
<references/> | <references/> | ||
[[Category:Anticonvulsants]] | [[Category:Anticonvulsants]] | ||
Latest revision as of 01:09, 20 August 2019
Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures;
with lower bone health disturbances[1][2] higher dosis of the drug enhances the risk of hepatocellular carcinoma [3]
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recommended[4]
alteration of CyP450 may conduce to thyroid hormone function disturbances (observed phenobarbitone, carbamazepine) [5]
Persistence
Warfarin
Warfarin and phenytoin drug interaction with possible purple glove syndrome
Rhabdomyolysis
A Case of Phenytoin-induced Rhabdomyolysis in Status Epilepticus
Psychosis
Psychosis as Harbinger of Phenytoin Toxicity
Medicinal Chemistry
ATC
N03AB02
Interwiki via Wikidata
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084542/
- ↑ The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism
- ↑ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study
- ↑ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations
- ↑ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study