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Phenytoin: Difference between revisions
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Phenytoin is an anticonvulsant used in tonic clonic and partial seizures | Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures; | ||
with lower bone health disturbances<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084542/</ref><ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000640/ The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism] | |||
</ref> | |||
higher dosis of the drug enhances the risk of hepatocellular carcinoma | higher dosis of the drug enhances the risk of hepatocellular carcinoma | ||
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102649/ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study]</ref> | <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102649/ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study]</ref> | ||
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recommended<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020771/ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations]</ref> | |||
alteration of CyP450 may conduce to thyroid hormone function disturbances (observed [[phenobarbitone]], [[carbamazepine]]) | |||
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966235/ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study]</ref> | |||
==Persistence== | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008541/ Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.] | |||
==Warfarin== | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936086/ Warfarin and phenytoin drug interaction with possible purple glove syndrome] | |||
==[[Rhabdomyolysis]]== | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933680/ A Case of Phenytoin-induced Rhabdomyolysis in Status Epilepticus] | |||
==Psychosis== | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721166/ Psychosis as Harbinger of Phenytoin Toxicity] | |||
==Medicinal Chemistry== | |||
[https://www.ncbi.nlm.nih.gov/pubmed/8681892 Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools.] | |||
==[[ATC]]== | |||
[https://www.whocc.no/atc_ddd_index/?code=N03AB02 N03AB02] | |||
{{wikidata|Q410400}} | |||
<references/> | <references/> | ||
[[Category:Anticonvulsants]] | |||
Latest revision as of 01:09, 20 August 2019
Phenytoin or 5,5-Diphenyl-imidazolidine-2,4-dione is an anticonvulsant used in tonic clonic and partial seizures;
with lower bone health disturbances[1][2] higher dosis of the drug enhances the risk of hepatocellular carcinoma [3]
Toxic epidermal necrolysis was observed and therapeutic monitoring is highly recommended[4]
alteration of CyP450 may conduce to thyroid hormone function disturbances (observed phenobarbitone, carbamazepine) [5]
Persistence
Warfarin
Warfarin and phenytoin drug interaction with possible purple glove syndrome
Rhabdomyolysis
A Case of Phenytoin-induced Rhabdomyolysis in Status Epilepticus
Psychosis
Psychosis as Harbinger of Phenytoin Toxicity
Medicinal Chemistry
ATC
N03AB02
Interwiki via Wikidata
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084542/
- ↑ The Impact of Anti-Epileptic Drugs on Growth and Bone Metabolism
- ↑ Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population-based case-control study
- ↑ Phenytoin-induced toxic epidermal necrolysis: Review and recommendations
- ↑ Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study