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Cannabis (drug): Difference between revisions
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<small>unknown efficacy in epilepsy</small><ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068473/pdf/ndt-12-2605.pdf</ref> | <small>unknown efficacy in [[epilepsy]] </small> | ||
The Cannabis sativa plant contains more than 400 compounds, of which 100 are known as phytocannabinoids. The two cannabinoids with the highest concentrations in cannabis are delta9-tetrahydrocannabinol (Δ9-THC), responsible for most of the psychotomimetic effects of the drug, and cannabidiol (CBD), the most common non-psychoactive cannabinoid | <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068473/pdf/ndt-12-2605.pdf Managing drug-resistant epilepsy: challenges and solutions]</ref> | ||
<ref>Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol</ref> | <ref>[https://www.ncbi.nlm.nih.gov/pubmed/26941559 Is the medical use of cannabis a therapeutic option for children?]</ref> | ||
The Cannabis sativa plant contains(<ref>http://www.agriculture.pa.gov/Protect/PlantIndustry/NIPPP/Documents/marijuana%20article.pdf</ref>) more than 400 compounds, of which 100 are known as phytocannabinoids. The two cannabinoids with the highest concentrations in cannabis are delta9-tetrahydrocannabinol (Δ9-THC), responsible for most of the psychotomimetic effects of the drug, and cannabidiol ([[Epidiolex|CBD]]), the most common non-psychoactive cannabinoid | |||
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043219/ Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol]</ref> | |||
==Links== | |||
[https://www.ncbi.nlm.nih.gov/pubmed/26835389 Cannabinoids for pediatric epilepsy? Up in smoke or real science?] | |||
===Medical Cannabis=== | |||
Kolikonda et al. 2016 | |||
<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911937/pdf/icns_13_3-4_23.pdf Medical Cannabis for epilepsy Innovations clin.neurosci 13(3-4):]</ref> | |||
===Entourage effect=== | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604191/ Cannabinoids and Epilepsy] | |||
Ben Shabat et al 1998. [https://www.ncbi.nlm.nih.gov/pubmed/9721036 An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity Eur J Pharmacol.] | |||
<references/> | <references/> | ||
Latest revision as of 14:05, 11 July 2018
unknown efficacy in epilepsy [1] [2]
The Cannabis sativa plant contains([3]) more than 400 compounds, of which 100 are known as phytocannabinoids. The two cannabinoids with the highest concentrations in cannabis are delta9-tetrahydrocannabinol (Δ9-THC), responsible for most of the psychotomimetic effects of the drug, and cannabidiol (CBD), the most common non-psychoactive cannabinoid [4]
Links
Cannabinoids for pediatric epilepsy? Up in smoke or real science?
Medical Cannabis
Kolikonda et al. 2016 [5]
Entourage effect
Ben Shabat et al 1998. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity Eur J Pharmacol.
- ↑ Managing drug-resistant epilepsy: challenges and solutions
- ↑ Is the medical use of cannabis a therapeutic option for children?
- ↑ http://www.agriculture.pa.gov/Protect/PlantIndustry/NIPPP/Documents/marijuana%20article.pdf
- ↑ Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol
- ↑ Medical Cannabis for epilepsy Innovations clin.neurosci 13(3-4):