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Midazolam: Difference between revisions

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Status epilepticus
Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.<ref>Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.</ref>


lorazepam>diazepam<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.</ref>
==Weblinks==
<ref>http://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813</ref><references/>
[[Status epilepticus]]
== ==
[[lorazepam]]>[[diazepam]]<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/pdf/12883_2015_Article_486.pdf Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.]</ref>
<ref>
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/ Pharmacotherapy for Status Epilepticus]</ref>
<ref>[http://www.nice.org.uk/guidance/cg137/resources/epilepsies-diagnosis-and-management-35109515407813 ]</ref>
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211107/pdf/nihms311183.pdf RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): A double-blind randomized clinical trial of the efficacy of IM midazolam versus IV lorazepam in the pre-hospital treatment of status epilepticus by paramedics]</ref>
 
<gallery>
File:Midazolam_ball-and-stick_model.png
File:Mitte x-Midazolam.jpg
 
</gallery>
 
==ATC==
psycholeptics
 
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5
|colspan=2| <center>
: [[wikipedia:midazolam|midazolam]]
<ref>http://www.whocc.no/atc_ddd_index/?code=N05CD08</ref></center>
|}
 
[[wikipedia:midazolam|midazolam]]
<references/>
[[Category:GABAA receptor positive allosteric modulators]]

Latest revision as of 19:31, 13 October 2017

Midazolam is a benzodiazepine with the advantage of multiple routes of administration, due to its water solubility. At physiologic pH the ring structure of midazolam closes and it becomes highly lipophilic, crossing the blood-brain barrier rapidly.[1]

Weblinks

Status epilepticus

lorazepam>diazepam[2] [3] [4] [5]

ATC

psycholeptics

midazolam
[6]

midazolam

  1. ↑ Patsalos PN, Bell DM, Richards G, Sander JWAS, Oxley JR, Dhillion S, Cromarty J. Pharmacokinetic evaluation of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsia. 1991;32(suppl. 1):29.
  2. ↑ Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.
  3. ↑ Pharmacotherapy for Status Epilepticus
  4. ↑ [1]
  5. ↑ RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): A double-blind randomized clinical trial of the efficacy of IM midazolam versus IV lorazepam in the pre-hospital treatment of status epilepticus by paramedics
  6. ↑ http://www.whocc.no/atc_ddd_index/?code=N05CD08
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