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Primidone: Difference between revisions
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Primidone is an [[antiepileptic drug|anticonvulsant]] that is metabolized to phenylethylmalonamide (PEMA) and [[phenobarbitone|phenobarbital]]<ref>[http://www.neurology.org/content/64/12/2008.full.pdf+html Practice Parameter:Therapies for essential tremor Report of the Quality Standards Subcommittee of the American Academy of Neurology]</ref>, historically considered a prodrug of phenobarbital<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424120/pdf/ndt-0104-329.pdf The history of barbiturates a century after their clinical introduction]</ref>, nevertheless it is superior against tremor | |||
<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790207/pdf/tre-06-356-7522-1.pdf Essential Tremor: What We Can Learn from Current Pharmacotherapy</ref> | <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790207/pdf/tre-06-356-7522-1.pdf Essential Tremor: What We Can Learn from Current Pharmacotherapy]</ref> | ||
<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766376/pdf/nihms-480525.pdf Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors</ref> | <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766376/pdf/nihms-480525.pdf Molecular Mechanisms of Antiseizure Drug Activity at GABAA Receptors]</ref> | ||
Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner | |||
Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner | ==[[ATC]]== | ||
antiepileptic drugs | |||
<gallery> | |||
File:Primidone_ball-and-stick.png | |||
</gallery> | |||
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5 | |||
|colspan=2| <center> | |||
: [[wikipedia:primidone|primidone]] | |||
<ref>http://www.whocc.no/atc_ddd_index/?code=N03AA03</ref></center> | |||
|} | |||
<ref>[https://www.ncbi.nlm.nih.gov/pubmed/27843822 Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner]</ref> | |||
==Links== | ==Links== | ||
[http://www.jle.com/download/epd-303433-interactions_between_antiepileptic_drugs_and_between_antiepileptic_drugs_and_other_drugs--WDhqcX8AAQEAAG@xeO4AAAAJ-a.pdf Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs] | |||
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242891/pdf/11606_2014_Article_2907.pdf Factors Associated with Ordering Laboratory Monitoring of High-Risk Medications] | |||
de Leon, J 2015 [http://www.elsevier.es/en-revista-revista-psiquiatria-salud-mental-486-articulo-the-effects-antiepileptic-inducers-in-S2173505015000175 Efectos de los inductores antiepilépticos en la neuropsicofarmacología: una cuestión ignorada. Parte I: Resumen para los clínicos de la situación actual] | |||
{{Wikidata|Q420383}} | |||
{{refs}} | |||
[[Category:Anticonvulsants]] | |||
Latest revision as of 00:49, 26 August 2017
Primidone is an anticonvulsant that is metabolized to phenylethylmalonamide (PEMA) and phenobarbital[1], historically considered a prodrug of phenobarbital[2], nevertheless it is superior against tremor [3] [4] Chronic high-cumulative doses have shown to increase the fracture risk in a dose-dependent manner
ATC
antiepileptic drugs
Links
Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs
Factors Associated with Ordering Laboratory Monitoring of High-Risk Medications
