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Lorazepam: Difference between revisions
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[[Status epilepticus|Status epilepticus]], [[International League Against Epilepsy | | [[Status epilepticus|Status epilepticus]], [[International League Against Epilepsy |ILAE]] view as a seizure that persists for a sufficient lengh of time, maybe 5-10 (focal) minutes. | ||
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/ Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry]</ref> | <ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641362/ Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry]</ref> | ||
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==Other agents == | ==Other agents == | ||
lorazepam>[[ | lorazepam>[[phenytoin]] | ||
===midazolam=== | ===midazolam=== | ||
[[Midazolam]] (or lorazepam i.v.) controls effectively 63-73% early SE<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus]</ref> | [[Midazolam]] (or lorazepam i.v.) controls effectively 63-73% early SE<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus]</ref> | ||
==clonazepam== | ==clonazepam== | ||
[[clonazepam]] is more lipophylic that lorazepam, but less lipophilic than diazepam(Congdon et Forsythe | [[clonazepam]] is more lipophylic that lorazepam, but less lipophilic than [[diazepam]] (Congdon et Forsythe (1980) Epilepsia 21:97) | ||
==[[Levetiracetam|Levetirazetam]]== | ==[[Levetiracetam|Levetirazetam]]== | ||
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see also Trinka et al 2015 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus] Drugs 1491-1521. | see also Trinka et al 2015 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559580/pdf/40265_2015_Article_454.pdf Pharmacotherapy for Status Epilepticus] Drugs 1491-1521. | ||
[http://www.hkmj.org/system/files/hkmj166025.pdf Review and update Hong kong epilepsy guidelines on status epilepticus] | |||
{{Wikidata|Q408265}} | {{Wikidata|Q408265}} | ||
<references/> | <references/> | ||
[[Category:GABAA receptor positive allosteric modulators]] | |||
Latest revision as of 20:07, 19 May 2017
sufficient lengh of time (viewed as 30 min.period)
Status epilepticus, ILAE view as a seizure that persists for a sufficient lengh of time, maybe 5-10 (focal) minutes.
[1]
diazepam
intravenous
Other agents
lorazepam>phenytoin
midazolam
Midazolam (or lorazepam i.v.) controls effectively 63-73% early SE[2]
clonazepam
clonazepam is more lipophylic that lorazepam, but less lipophilic than diazepam (Congdon et Forsythe (1980) Epilepsia 21:97)
Levetirazetam
comparison
Propofol
recruitment problem
see also Trinka et al 2015 Pharmacotherapy for Status Epilepticus Drugs 1491-1521.
Review and update Hong kong epilepsy guidelines on status epilepticus
