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Carbamazepine: Difference between revisions

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structure related to [[imipramin]]
[[File:5H-Dibenzo(b,f)azepine numbering.svg.png|thumb|left]]
structure related to [[imipramin]][[File:Carbamazepine3Dan.gif|miniature]]
[[File:Tegretol.jpg|thumb|left]]
can form five polymorphic states, with low water solubility
<ref>Halliwell RA, Bhardwaj RM, Brown C, Briggs NEB, Dunn J, Robertson J,Nordon A, Florence AJ, Spray drying as a reliable route to produce metastable carbamazepine form IV, Journal of Pharmaceutical Sciences (2017), doi: 10.1016/j.xphs.2017.03.045.</ref>
== ==


can form five polymorphic states<ref>
Carbamazepine teratogenicity is relatively specific to [[spina bifida]], though the risk is less than with [[valproate|valproic acid]]<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996546/ Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study]</ref>
<refHalliwell RA, Bhardwaj RM, Brown C, Briggs NEB, Dunn J, Robertson J,Nordon A, Florence AJ, Spray drying as a reliable route to produce metastable carbamazepine form IV, Journal of Pharmaceutical Sciences (2017), doi: 10.1016/j.xphs.2017.03.045.</ref>
<ref>[http://www.scielosp.org/pdf/spm/v54n6/a06v54n6.pdf Malformaciones congenitas en hijos de madres epilépticas con y sin tratamiento con anticonvulsivantes]</ref>
[[spina bifida]]


[[Stevens-Johnson syndrome]]
[[Stevens-Johnson syndrome]]<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372085/ HLA-B*15:21 and carbamazepine-induced Stevens-Johnson syndrome: pooled-data and in silico analysis.]</ref><ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296452/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296452/ Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case]</ref>
<ref>https://www.drugs.com/monograph/carbamazepine.html</ref>
 
"there is any association between sexual dysfunctions and various [[antiepileptic drug|AEDs]] in the treatment, except for carbamazepine"
<ref>[https://www.ncbi.nlm.nih.gov/pubmed/28315500 Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs: a prospective study]</ref>


==Links==
==Links==
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[https://www.jstage.jst.go.jp/article/internalmedicine/56/8/56_56.7910/_pdf Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine]
[https://www.jstage.jst.go.jp/article/internalmedicine/56/8/56_56.7910/_pdf Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine]


[https://www.ncbi.nlm.nih.gov/pubmed/28401072 The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine]
===Rapamycin===
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321171/ Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease]
===Extended release===
===Extended release===
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279715/pdf/nihms614995.pdf The effects of carbamazepine on prefrontal activation in manic  
 
youth with bipolar disorder]
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279715/pdf/nihms614995.pdf The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder]
<references/>
==[[ATC code N03|ATC]]==
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5
|colspan=2| <center>
: [[wikipedia:carbamazepine|carbamazepine]]
[http://www.whocc.no/atc_ddd_index/?code=N03AF01 N03AF01]</center>
|}
<ref>https://www.whocc.no/atc_ddd_index/?code=N03AF01</ref>
 
{{refs}}
[[Category:anticonvulsants]]

Latest revision as of 15:15, 25 October 2024

structure related to imipraminminiature

can form five polymorphic states, with low water solubility [1]

Carbamazepine teratogenicity is relatively specific to spina bifida, though the risk is less than with valproic acid[2] [3]

Stevens-Johnson syndrome[4][5] [6]

"there is any association between sexual dysfunctions and various AEDs in the treatment, except for carbamazepine" [7]

Links

Spray drying as a reliable route to produce metastable carbamazepine form IV

Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes

Transient Splenial Lesion Following Abrupt Withdrawal of Carbamazepine

The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine

Rapamycin

Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

Extended release

The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder

ATC

carbamazepine
N03AF01

[8]

References

References:
  1. ↑ Halliwell RA, Bhardwaj RM, Brown C, Briggs NEB, Dunn J, Robertson J,Nordon A, Florence AJ, Spray drying as a reliable route to produce metastable carbamazepine form IV, Journal of Pharmaceutical Sciences (2017), doi: 10.1016/j.xphs.2017.03.045.
  2. ↑ Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study
  3. ↑ Malformaciones congenitas en hijos de madres epilépticas con y sin tratamiento con anticonvulsivantes
  4. ↑ HLA-B*15:21 and carbamazepine-induced Stevens-Johnson syndrome: pooled-data and in silico analysis.
  5. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296452/ Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case
  6. ↑ https://www.drugs.com/monograph/carbamazepine.html
  7. ↑ Relation between sexual dysfunctions and epilepsy, type of epilepsy, type of antiepileptic drugs: a prospective study
  8. ↑ https://www.whocc.no/atc_ddd_index/?code=N03AF01
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