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Nephrotic syndrome

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Disease classification WHO
N04 Nephrotic syndrome

Nephrotic syndrome is a nonspecific kidney disorder characterized by a number of signs of disease: proteinuria, hypoalbuminemia and edema. It is characterized by an increase in permeability of the capillary walls of the glomerulus leading to the presence of high levels of protein passing from the blood into the urine (proteinuria at least 3.5 grams per day per 1.73m2 body surface area); (> 40 mg per square meter body surface area per hour) low levels of protein in the blood (hypoproteinemia or hypoalbuminemia), ascites and in some cases, edema; high cholesterol (hyperlipidaemia or hyperlipemia) and a predisposition for coagulation[1]


Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome Molecular Cell 1, 575–582


  • Jacob Churg, Renee Habib, Richard H.R. White 1970

Pathology of the Nephrotic Syndrome im Children: A Report for the International Study of Kidney Disease in Children Lancet 295:1299–1302