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Lennox–Gastaut syndrome (LGS) is a difficult-to-treat form of childhood-onset epilepsy that most often appears between the second and sixth year of life. LGS is characterized by a triad of signs including frequent seizures of multiple types, an abnormal EEG pattern of less than 2.5 Hz slow spike wave activity,
LGS children with a history of perinatal hypoxia or other perinatal event have earlier age of onset of seizures
LGS may evolve from West syndrome
Lennox-Gastaut syndrome: A consensus approach to differential diagnosis epilepsia 55(4):4-9 (2014)
Surgical options for patients with Lennox-Gastaut syndrom epilepsia suppl. 55:21 4:21-8. doi: 10.1111/epi.12742.
Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study