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LYK5

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The human gene encoding the LYK5 protein, also known as STRAD (STE20-like pseudokinase, STE20-like related adapter protein). The STRAD protein has a STE20-like kinase domain, but has altered amino acid residues responsible for catalytic activity, hence being classified as pseudokinase. It is known that STRAD forms in vivo a triple complex with LKB1 kinase and MO25 protein, and is essential for the proper functioning of LKB1 in the cell[1]

Mutations in the LYK5/STRADα gene are associated with polyhydramnios, megalencephaly and symptomatic epilepsy.[2]

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