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<gallery>File:Valproic_acid3Dan.gif</gallery>
Valproic acid is a carboxylic acid, a well probed [[Antiepileptic drug|AED]]<ref>[http://www.ncbi.nlm.nih.gov/pubmed/26608980 Long-term Effectiveness of Antiepileptic Drug Monotherapy in Partial Epileptic Patients: A 7-year Study in an Epilepsy Center in China]</ref>, with a high teratogenic potential.<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892321/pdf/BCN-7-165.pdf Hallervorden-Spatz Syndrome with Seizures ]</ref> <ref>[http://www.tijdschriftvoorpsychiatrie.nl/assets/articles/58-2016-3-artikel-solignac.pdf Een meisje met foetaal valproaatsyndroom en autismespectrumstoornis ]</ref>
Valproic acid is a carboxylic acid,
<ref>[http://www.psychiatrist.com/JCP/article/_layouts/ppp.psych.controls/BinaryViewer.ashx?Article=/JCP/article/Pages/2016/v77n04/v77n0420.aspx&Type=Article Should women in childbearing potential be prescribed valproate?]</ref>,
 
may alter bone metabolism
 
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855910/pdf/12887_2016_Article_597.pdf Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children-a medical center experience]</ref>
erithema nodosum was observed associated with valproate therapy
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695434/pdf/ad-27-765.pdf Erythema Nodosum Associated with Valproate ]</ref>
 
==Links==
[http://flexikon.doccheck.com/de/Valproins%C3%A4ure?utm_source=www.doccheck.flexikon&utm_medium=web&utm_campaign=DC%2BSearch FLexikon:Valproinsäure]
 
===Fanconi syndrome===
 
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900196/pdf/10.1177_2054270415623145.pdf Progressive myoclonic epilepsy with Fanconi syndrome]
===Autism===
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893673/pdf/srep27400.pdf Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure]
 
===Hipothyroidism===
[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864769/pdf/40681_2016_Article_12.pdf Hypothyroidism may exacerbate valproate-related hyperammonemic delirium]
 
==Vitamin B2==
 
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623793/pdf/epj-07-1344.pdf Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial]</ref>
 
==ATC==
==ATC==
http://www.whocc.no/atc_ddd_index/?code=N03AX11
http://www.whocc.no/atc_ddd_index/?code=N03AX11


==Links==
{| style="background:Ivory; color:black" border=1 cellspacing=1 cellpadding=5
http://flexikon.doccheck.com/de/Valproins%C3%A4ure?utm_source=www.doccheck.flexikon&utm_medium=web&utm_campaign=DC%2BSearch
|colspan=2| <center><gallery>File:Valproic acid.svg.png</gallery>
: [[wikipedia:valproate|valproate]]
<ref>http://www.whocc.no/atc_ddd_index/?code=N03AG01</ref></center>
|}
==[[Valproate XR|extended release]]==
https://www.drugs.com/pro/divalproex-extended-release.html
 
{{refs}}
 
 
{{Wikidata|Q240642}}
[[Category:Epilepsy]]
[[Category:Anticonvulsants]]

Latest revision as of 22:47, 18 May 2019

Valproic acid is a carboxylic acid, a well probed AED[1], with a high teratogenic potential.[2] [3] [4],

may alter bone metabolism

[5] erithema nodosum was observed associated with valproate therapy [6]

Links

FLexikon:Valproinsäure

Fanconi syndrome

Progressive myoclonic epilepsy with Fanconi syndrome

Autism

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure

Hipothyroidism

Hypothyroidism may exacerbate valproate-related hyperammonemic delirium

Vitamin B2

[7]

ATC

http://www.whocc.no/atc_ddd_index/?code=N03AX11

valproate
[8]

extended release

https://www.drugs.com/pro/divalproex-extended-release.html

References

References:


Q240642 at Wikidata  Interwiki via Wikidata