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Spina bifida is a complex disorder which arises at the neural tube during embryonic development. This is called a neural tube defect. Anencephaly is a less well-known example of a neural tube defect.
With spina bifida, the spine do not close properly around the spinal cord (open rug). It occurs in 4.5 out of 10,000 births. If the disability occurs once every family, the chance of a child with this disability is ten times larger. In Southeast Asia, the deviation less common (2.5 per 10,000 births) .
The term spina bifida was given by the Dutchman Nicolaes Tulp in 1637.
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- Risk factors, organ weight deviation and associated anomalies in neural tube defects: A prospective fetal and perinatal autopsy series
- Prevention of neural tube defects with folic acid: The Chinese experience
- How I Do It: Management of spina bifida in a hospital in The People's Republic of China
- CDC Grand Rounds: Additional Opportunities to Prevent Neural Tube Defects with Folic Acid Fortification