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Rufinamide

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Lennox-Gastaut is a low prevalence epileptic syndrome (1:10000), and Cochrane Epilepsy Group concluded that treatment remain unconclusive. Otsuka et al. (2014) state rufinamide as an efficacious and well tolerated AED [1](cf. Alssad et Coren 2014) [2]

"Rufinamide received the status of orphan drug for epilepsy in 2004 in Europe" [3]

It is an inductor of CYP 450

Weblinks

FLexikon:Rufinamid

Pharmawiki:Rufinamid

ATC

https://www.whocc.no/atc_ddd_index/?code=N03AF03

References

References:
  1. ↑ Rufinamide as an adjunctive therapy for Lennox-Gastaut syndrome: a randomized double-blind placebo-controlled trial in Japan
  2. ↑ Exposure to rufinamide and risks of CNS adverse events in drug-resistant epilepsy: a meta-analysis of randomized, placebo-controlled trials
  3. ↑ Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience

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